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KMID : 0881720110260040398
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Journal of Food Hygiene and Safety
2011 Volume.26 No. 4 p.398 ~ p.402
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Anti-tumorigenic Effect of DIM-pPhBr and DIM-pPhF Originating from Cruciferous Vegetables in KB Human Oral Squamous Cell Carcinoma Through Apoptotic Cell Death
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Cho Hyun-Tai
Choi Eun-Sun
Cho Nam-Pyo
Cho Sung-Dae
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Abstract
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Cruciferous vegetables including diindolylmethane (DIM) have been shown to have anticancer activity. Especially, DIM-pPhBr and DIM-pPhF used in this study was reported to have more effective and less toxic effects than DIM. However, there is no report presenting their anti-tumorigenic activity in oral cancer. In the present study, we examined the effects of DIM-pPhBr and DIM-pPhF on the cell proliferation and apoptosis in KB human oral cancer cells. DIM-pPhBr and DIM-pPhF decreased cell proliferation and induced apoptosis evidenced by western blot analysis, DAPI staining and sub-G1 population. This provides the first evidence that DIM-pPhBr and DIM-pPhF originating from cruciferous vegetables induce apoptotic cell death in human oral cancer cells to inhibit cancer cell proliferation.
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KEYWORD
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DIM-C-pPhBr, DIM-C-pPhF, Oral Squamous Cell Carcinoma, Apoptosis
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